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APPLICATOR DELIVERY SYSTEM FOR CELOX AGENT TO DEEP PENETRATING WOUNDS

CELOX™ is a high performance chitosan-derived hemostatic designed to stop lethal bleeding fast. It is easy to use, extremely effective (clots blood in 30 seconds), and safe (is a CE Marked Class III Medical Device). CELOX comes in four different delivery systems, providing a commitment to aiding the caregiver in treating a variety of difficult and deep wounds. It also does not generate heat and will not burn the casualty or care giver. CELOX works independently of the body’s normal clotting processes. Its clotting ability has been proven to work in hypothermic conditions and in the presence of common anticoagulants such as Coumadin and Heparin.

The CELOX-A applicator and plunger delivery system makes it possible for the hemostatic agent to reach deep into small penetrating wounds, getting straight to the source of the bleeding.

HOW CELOX WORKS

When placed directly into a bleeding wound and subjected to pressure, the positively charged CELOX granules cross-link with negatively charged red blood cells, forming a sticky pseudo clot that blocks blood flow. This clot sticks well to moist tissue to plug the bleeding site. CELOX does not set off the normal clotting cascade, it only clots the blood it comes directly into contact with. CELOX also does not set off a blood clotting response which would lead to clots being formed at a distance to the product.

CHITOSAN

CELOX is made of chitosan, a compound derived from shrimp shells. Chitosan has proven antimicrobial properties and is not a procoagulant. Chitosan is broken down and absorbed through normal metabolic pathways and has an extensive history of use in vascular closure and in human cardiac surgery.

CELOX has a three year history of use in emergency, military, and retail first aid with no reported incidents. An external review was commissioned on the safety of CELOX’s ingredients in the body and concluded that CELOX was safe to use internally in surgery and that residual quantities presented no risk.

BENEFITS AND FEATURES

• Proven to control arterial bleeding within minutes
• Works in hypothermic conditions
• FDA cleared to work on anticoagulated blood
• No heat – no burning
• Sterile, waterproof packaging
• Easy to irrigate from wound
• Applied using basic first aid skills

TECHNICAL DATA

• 6g (0.2oz) applicator/plunger

CE Approved

WHO USES CELOX

• EMS Personnel
• Military Medics
• Law Enforcement
• Wilderness Rescue

PRODUCT INFORMATION

celox page
LEARN ABOUT CELOX, the original temporary traumatic wound treatment comprised of absorbent hemostatic granules

celoxgauze page
LEARN ABOUT CELOX GAUZE, rolled gauze coated with CELOX hemostatic agent

celox trauma gauze page
LEARN ABOUT CELOX TRAUMA GAUZE, a dual purpose gauze for treating traumatic wounds and 1st and 2nd degree burns

celoxa page
LEARN ABOUT CELOX-PRO, a hemostatic agent for wound treatment in hospitals and clinics

CELOX Testimonials (click to open and close)

First case was a 80 year old female with renovascular hypertension and need for dialysis. To make matter worse she was on Coumadin and was had an extremely high blood pressure. She needed her dialysis to reduce the pressure. She developed a spontaneous bleed in her dialysis shunt. In fact it was extremely high pressure bleeding and would not stop with pressure and pressure dressing. She came to the ED with a BP of 190/70 active bleeding in her arm and an INR of 2.1. I applied Celox and a pressure dressing and 10 min later she was bloodless and after washing off the Celox she went on to dialysis.
Case two was a 48 year old male with varicose veins in his leg and foot. EMS was called after one began bleeding. Simple pressure was not very effective in stopping it. EMS applied Celox and bandaged the foot. He came to the ED with no further bleeding. Celox was washed off and he was discharged without further need for treatment.
What a wonderful outcome to two problematic cases with a very simple solution. It is not just gunshot and stab wounds that benefit from this wonderful product, but every day events.
Marvin Wayne, MD, FACEP, FAAEM

Wanted to let you know that we used Celox in a patient with a venous stasis wound of the leg that would not stop bleeding for several days – she had a coagulopathy on top of the physical wound. We used celox and the bleeding stopped immediately – we left it in and did not wash it out – the wound seemed to heal well, although she will likely always have the wound…
Thanks again
John P. Pryor, MD, FACS

I had the opportunity to use Celox for unstoppable atraumatic bleeding from an external tumor. I stripped the existing bandaging off the area, applied the Celox all the way around and over the tumor, then placed trauma dressings and applied pressure with Coban. During the transport to the hospital, no further bleeding was noted. Once at the hospital, most of the Celox was removed, but there was no blood loss. The ED staff was very impressed, as was I. This call would have definitely turned out differently with Celox. What a wonderful product!
Eric Augustus
Critical Care Paramedic

We had a elderly lady with a massive facial tumor who developed bleeding from her tumor at home. Fire departments responded to the scene and were not able to control bleeding. Evaluation by paramedics with the ambulance service not able to stop the bleeding with pressures either. The paramedic then chose to use Celox and with pressure the bleeding was rapidly controlled and the patient was transported to the emergency room for definitive care. The emergency department was very happy with the care provided to the patient
Erling Oksenholt DO FACEP, FACOEP

As I was passing over the bridge I witness an overturned SUV on the left hand side, inside the grassy median. I turned my Blue Emergency Signal Lights on and slowed to a stop. I got out of my truck and approached the citizens that were stumbling out of the vehicle. As I approached I noticed 2 small female children, 1 middle aged Hispanic female and 1 middle aged Hispanic male. I ran to the girls and asked if they were ok. I then asked if the Middle Aged female was ok. They did not understand me very well because their primary language seemed to be Spanish. I then approached the Middle aged male and saw that he was holding an infant that seemed to be around 1 year of age. The infant was bleeding profusely. I open the blanket the Hispanic male had him in and realized that the infants head had been cut severely and looked to be fatal if not treated extremely quickly. The skin was cut an inch from the center of the forehead all the way down to the middle of the ear on the left hand side. The cut was 4 - 5 inches minimum. I told him to stay right here while I got my medical kit. I ran back to my truck. I got 2 blankets and my medical kit. I gave a blanket to the children and a blanket to the middle aged woman and told them to keep warm because it was 10 degrees with low visibility because of the wind and freezing fog. At that time another male ( off duty sheriff deputy) pulled over and took the children and put them in his truck. I approached the infant again and told the father that we need to place the skin back where it should be and then put CELOX on the wound to stop the bleeding or else the infant would die of blood loss. I instructed for the father to hold the infants head completely still and tell the boy to keep his eyes closed no matter what because the CELOX should not get in his eyes. The father did what I instructed. I then opened my medical kit, took out a pair of gloves and placed them on my hands to not contaminate the infant or myself. I then got the package of CELOX and an Abdominal wrap. I placed the skin back into place the best I could. I then took the bandage and placed it at a 45 degree angle on the wound to shield the wind from blowing the CELOX off the skin. I then poured the CELOX onto the skin and wrapped the bandage around the infants head. I tied off the bandage and wrapped a piece of tap around the bandage to secure it. I then took my permanent marker that was supplied in the medical kit and wrote, “CELOX - Hemostatic agent - used on infant.” I gave the package of CELOX for the father to hold and give to the paramedics. At this point a Texas State Police Officer appeared at the scene and soon after the EMS crew showed. I told the State Police Officer what happened and then told the EMS. One of the EMS crew members asked how I put it on there and said that I did it properly. He also said that if I wouldn’t have rendered aid or had a medical kit to this stature on my person the infant would have best case scenario severe brain damage due to massive blood loss or worst case scenario (most likely) the bleeding would have proven fatal because infants don’t have near as much blood as adults and he had already lost a lot of blood. I then gave my statement to the State Police Officer, Asked if they needed any other assistance and they said they were good to go. I left the scene and was on my way home again. If not for the product CELOX this infant would have died.
Zachary

I work as a Paramedic at Skyline Hospital in White Salmon, WA. I want to share my experience with the Celox product. Our crew was dispatched to a large caliber GSW to the chest. After isolating the right lung, both entrance and exit wounds were sealed using the Celox product. The patient was able to maintain excellent vitals through-out the transport to the receiving hospital. Celox enabled us to focus less on the injury and more on other life saving skills. All staff members involved commented on the lack of blood loss present for such a significant wound. After seeing the effectiveness of this product I recommend using Celox as the first-line in hemorrhage control agent.
Nicholas Puff
Paramedic


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CELOX-A Plunger and Applicator

PRODUCT LITERATURE

CELOX Overview Brochure CELOX-A Quick Fact Sheet
CELOX-A Instructional Poster CELOX Press Kit

INSTRUCTIONS FOR USE

CELOX-A Instructions Presentation

CELOX SAFETY

Position Paper on CELOX Safety

SUPPORTING DATA

Comparison of 10 hemostatic dressings in a groin puncture model in swine. Françoise Arnaud, PhD, Kohsuke Teranishi, MD, Toshiki Tomori, MD, Walter Carr, PhD, and Richard McCarron, PhD.

A New Hemostatic Agent: Initial Life-Saving Experience With Celox (Chitosan) in Cardiothoracic Surgery, Russell W. J. Millner, MD, FRCS (CTh), Alan S. Lockhart, FRCA, Helen Bird, FRCA, Christos Alexiou, PhD, FRCS (CTh). Departments of Cardiothoracic Surgery and Cardiothoracic Anesthesia, Blackpool Victoria Hospital, Blackpool, United Kingdom. 2009.

U.S. Navy Study
An Alternative Hemostatic Dressing: Comparison of CELOX, HemCon, and QuikClot; Buddy G. Kozen, MD, LCDR, MC, USN, Sara J. Kircher, BS, RLAT, Jose Henao, MD, LCDR, MC, USN, Fermin S. Godinez, DO, Andrew S. Johnson, MD, CDR, MC, USN

PRESS

singapore_army_link
Popular Science - December 2009
Best of What's New: Health
SAM MEDICAL CELOX TRAUMA GAUZE: A Bandage for Blood and Burns.

Emergency Global - June 2009
AMBULANCE: about Celox, the lifesaving haemostat
Celox is a lifesaving haemostat with the tested and proven ability to effectively stop bleeding within minutes.

eWorld of Trees - May 2009
Emergency First Aid Kits for Arborists and Loggers
Even if the situation isn’t particularly life threatening, proper aid can go a long way toward alleviating pain and minimizing damage.
Oregon Business Magazine - May, 2009
To your health

Though SAM Medical Products’ granular hemostatic agent, CELOX, is geared for gaping wounds in life-threatening blood loss, Steve Melia has found it handy for something a little more everyday.
grough.uk.com
Battlefield treatment helps rescuers save climber after fall
Mountain rescuers used an innovative medical treatment to help save the life of a climber at the weekend.
Law Officer-March 2008
Clotting Agents

Here’s the scoop on these lifesaving tools.
EMS Magazine-January 2008
EMS Expo 2007 Top Product Picks

CELOX-A from SAM Medical Products
Popular Science-July 2006
Trauma Tech: The Seafood Bandage

A new powder made from shrimp stops serious bleeding fast.

PRODUCT IMAGES FOR MEDIA AND DISTRIBUTORS

CELOX Images